Blue Eaglets soar in third week of NBTC 24

first_imgCONTRIBUTED PHOTOAteneo Blue Eaglets soared high in this week’s Chooks-to-Go/National Basketball Training Center 24 power rankings with pacesetter Kai Sotto now being trailed by teammate SJ Belangel.The 1-2 combo kept the Katipunan crew’s pristine 11-0 UAAP Season 80 record intact, allowing Belangel to eclipse Joel Cagulangan of La Salle Greenhills for the second spot.ADVERTISEMENT Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award View comments Jiro Manio arrested for stabbing man in Marikina FEU-Diliman playmaker RJ Abarrientos also earned himself a ticket to the top 10, while Joaqui Manuel of Ateneo has shot up to the top 20.Also making their entries in the weekly high school power rankings are reigning CESAFI MVP Beirn Laurente of University of Visayas and returning Joem Sabandal of Adamson.FEATURED STORIESSPORTSTim Cone, Ginebra set their sights on elusive All-Filipino crownSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSAfter winning title, time for LA Tenorio to give back to Batangas folkHere is the list for the third week of Chooks-to-Go NBTC 24, with last week’s rank in the parenthesis:Kai Sotto, center, Ateneo (1)SJ Belangel, guard, Ateneo (3)Joel Cagulangan, guard, La Salle Greenhills (2)Will Gozum, center, Mapua (4)L-Jay Gonzales, guard, FEU-Diliman (5)Rhayyan Amsali, forward, NU (7)CJ Cansino, forward, UST (8)Dave Ildefonso, forward, Ateneo (6)RJ Abarrientos, guard, FEU-Diliman (12)Clint Escamis, guard, Mapua (9)Terrence Fortea, guard, NU (11)Aaron Fermin, center, Arellano (10)Inand Fornilos, forward, CSB-LSGH (13)Evan Nelle, guard, San Beda (14)John Galinato, guard, Chiang Kai Shek (16)Warren Bonifacio, center, Mapua (15)Joaqui Manuel, forward, Ateneo (21)Raven Cortez, center, La Salle Zobel (18)Mac Guadaña, guard, Lyceum (17)Harvey Pagsanjan, guard, Hope Christian (19)Maui Cruz, guard, EAC (20)Joem Sabandal, guard, Adamson (N/A)Beirn Laurente, guard, UV (N/A)Harold Alarcon, guard, Tay Tung-Bacolod (22)Every week, a panel of coaches, sportswriters, and a statistician converge to come up with the weekly rankings to determine the top 24 high school players in the UAAP, CESAFI-NBTC, MMBL, and FCAAF tournaments, together with the recently concluded NCAA competition. LATEST STORIES Don’t miss out on the latest news and information. Nonito Donaire vs Naoya Inoue is BWAA 2019 Fight of the Year Michael Porter Jr. stays patient as playing time increases Newsome sets focus on helping Bolts open new PBA season on right trackcenter_img Years later, Roger Federer still on top Steam emission over Taal’s main crater ‘steady’ for past 24 hours Almazan vows to comeback stronger after finals heartbreak OSG plea to revoke ABS-CBN franchise ’a duplicitous move’ – Lacson Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew MOST READ OSG plea to revoke ABS-CBN franchise ’a duplicitous move’ – Lacson The players were ranked based on the following criteria: league stats, impact in team, team record, leadership, defense, offense, and level of competition.The top 24 players still on the board for the power rankings in early March will be picked to play in the SM-National Basketball Training Center (NBTC) High School All-Star Game later that month at Mall of Asia Arena.Sports Related Videospowered by AdSparcRead Nextlast_img read more

1 in custody for Charity supermarket robbery-shooting

first_img…shooting victim air-dashed to city hospitalOne suspect has since been apprehended by the Police for the shooting of the 18-year-old daughter of a Charity businesswoman during the commissioning of a robbery by two armed men on Monday evening at the family business.The alleged main suspect in the robberyThe helicopter that transported Mohammed to GeorgetownThe business remains closed following the shootingThe injured teen, Feiada Mohammed, is presently in a stable condition after she was air-dashed to a city hospital where she is being treated.Mohammed was shot to her head around 19:20h when the known suspects invaded the Manzoor Mohammed General Store in Charity, Essequibo Coast, Region (Pomeroon-Supenaam) under pretence as customers.Guyana Times understands that the two males entered the business establishment as the owner, 54-year-old Zareeda Mohammed, was closing for the day.One of the males, according to reports received, requested a bottle of Diamond Water; however, as Lisana Mohammed, a daughter of the business woman was to assist the men, she was held at gunpoint.Police sources told Guyana Times that at the time of the robbery, a female customer was held up and taken to the upper flat of the house. The two perpetrators then returned to the lower flat of the property, where they saw Feiada Mohammed and fired a shot in her direction as she attempted to sound an alarm.The bullet struck the young woman to her forehead. Panicked, the two bandits quickly escaped the scene of the crime.Mohamed was rushed to the Charity Hospital and then transferred to the Suddie Public Hospital where she remained in the Intensive Care Unit (ICU) until Tuesday, when an army helicopter was used to fly her to the city hospital.When this publication spoke with an uncle of the injured woman, he relayed that he was told that the men invaded the property where they ransacked and stole an undisclosed amount of cash.According to the man, at the time of the incident, a hotel which, is located next door to his supermarket, was blaring music.He noted that he was told by Zareeda Mohammed that the men entered as she was closing up but knowing them, she instructed them to hurry and purchase whatever they needed.“But after a few minutes passed and she didn’t see them coming out, she yell to ask them what going on because she couldn’t hear what was happening inside because of the loud music from the hotel,” the man explained.However, shortly after, the woman saw her daughter running towards her with a gunshot to her forehead.“She run out and tell she that bandits in the house, in the shop and that they tying up the other sisters and that they shot her. She say by time she start squeal and people come and they run into the place the bandits them get away from the back” the man disclosed.The men reportedly were only able to steal the cash earning from Monday’s sales.“They escape with the days sale, was three of them, they entered the upstairs from a door inside of the store and they ransack the house upstairs but I hear that they didn’t get anything else because when they heard the gun fire, they started to run” the uncle recalled.The man disclosed that he was instructed that Feiada Mohammed is in a stable condition as the young woman had regained consciousness.An investigation and manhunt have since been launched.last_img read more

McIlroy eyes Masters at Pebble Beach Pro-Am

first_imgMcIlroy, who returned to the top 10 last month after failing to win an event last year for the first time in nearly a decade, said he had taken positives from recent results.His runner-up spot in Dubai came after he blew a two-shot lead down the stretch to give China’s Li Haotong the biggest win of his career.However McIlroy said simply being in position to win had been encouraging.“I had two chances to win golf tournaments and I didn’t,” McIlroy said of his performances in Abu Dhabi and Dubai.“But great building blocks. I don’t want to dwell on them too much — I take them for what they are, which are good performances in a couple of pretty solid golf tournaments.“They were two good confidence builders going into this part of the season,” the four-time Major winner added.“I feel like the best way to prepare you for a big week like the Masters is to be in contention, feeling those nerves down the stretch. I feel like the more I play, the more chance I’m going to give myself to be in that position,” added McIlroy, who is playing this week’s tournament in California for the first time.Another former world number one, Australia’s Jason Day, is also satisfied with his form ahead of Pebble Beach.Day returned to the top 10 in the world rankings last month after defeating Alex Noren in a play-off at the Farmers Insurance Open at Torrey Pines. It was the Australian’s first title since the 2016 Players Championship.Day told reporters Wednesday he was eager to add to his career tally of 11 PGA Tour wins and one major.“Every mindset that I take into every tournament should be like, ‘This could be my last tournament,’” Day said.“Because I don’t know what’s happening around the corner. My back could be gone, and I may not be able to pick up a golf club again.“I need to go and try and win every single event, because who knows what’s going to happen around the corner.”0Shares0000(Visited 1 times, 1 visits today) 0Shares0000Rory McIlroy of Northern Ireland plays a shot during the Dubai Desert Classic at Emirates Golf Club on January 28, 2018 © AFP/File / GIUSEPPE CACACESAN FRANCISCO, United States, Feb 8 – Former world number one Rory McIlroy is hoping to build on recent near-misses in Abu Dhabi and Dubai as he steps up his Masters preparation on Thursday at the PGA Tour’s Pebble Beach Pro-Am.The Northern Irish star has enjoyed a solid start to the year, finishing in a tie for third at the Abu Dhabi Championship last month before a second place at the Dubai Desert Classic.last_img read more

Grande Prairie RCMP charge two males after firearm discharged in residence

first_imgAccording to Police, an investigation revealed a firearm had been discharged from the top floor residence, into the lower level residence. Two males were arrested and RCMP conducted a search of the area outside the residence and located a prohibited firearm, along with shotgun and rifle ammunition. On November 24, RCMP received a 911 call reporting shots had been fired in a multi-family home in the neighbourhood of Lakeland. GRANDE PRAIRIE, A.B. – Grande Prairie RCMP have charged two males after a firearm was discharged inside a residence. – Advertisement -Further investigations found stolen mail and cocaine. Police also recovered electronics, jewelry and clothes that were stolen from a residence the previous day. center_img Sutton was held in custody and appeared in court on December 4, while Howat was released and is scheduled to appear in court on December 12. Advertisement Charged was 21-year-old Dylan Sutton and 25-year-old Christopher Howat, both of Grande Prairie. last_img read more

SEND US IN YOUR CHRISTMAS AND NEW YEAR GREETINGS AT THIS SPECIAL TIME

first_imgDonegaldaily.com is now read by Donegal people in more than 125 countries around the globe on a daily basis.We are the quickest way for people from Letterkenny to Bundoran to Buncrana who have found themselves overseas to keep in touch with what is happening back here at home.With the click of a mouse more than 112,000 Donegal people around the globe are catching up with the latest happenings. We know it’s not the same as being here but we will continue to try and bring you the news across Donegal as soon as it happens.As Christmas and the New Year approaches we also want to let you know that we and your families here in Donegal are thinking of you.That’s why we want you all to send us in festive greetings to your families here at home.And we also want Donegaldaily.com readers at home to send greetings to their loved ones abroad. Take two minutes, write down a message and leave it in the comment box below this article remembering to leave your name and who you are sending the greeting to.It doesn’t matter how long or short it is and we’ll put it up.And if you want to include pictures, then please send us some.COMMENTSWe would like to wish John Watters who’s living in Melbourne,Australia a very Merry Christmas & Best Wishes for the new year!!! Can’t wait to see him for Catherine’s (sisters) wedding in February !!! We all miss you and LOVE you to bits!!!! Sheila xoxoxo (sister) Thanks Donegal Daily, Happy Christmas to you all!!SEND US IN YOUR CHRISTMAS AND NEW YEAR GREETINGS AT THIS SPECIAL TIME was last modified: December 25th, 2011 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:Christmas and New Year greetingsdonegaldaily.comlast_img read more

Alaska Peninsula state oil, gas leases sold

first_img Shell submitted identical bids of $5.02 per acre generating $28,911 per tract on its 33 successful bids. Hewitt bid $21.14 per acre, and a total of $121,767 each, for two tracts. It bid $6.11 per acre for two other tracts. The 10-year leases have a fixed royalty rate of 12.5 percent. Local support for the sale contributed to preparing lease details in two years rather than the usual three, said Mark Myers, director of the Alaska Division of Oil and Gas. The communities want local energy supplies and a stimulus to the economy, he said. The state and communities negotiated restrictions to protect the environment but still make drilling viable, Myers said. The leases ban offshore drilling. ANCHORAGE, Alaska – The first sale of state oil and gas leases in 22 years on the Alaska Peninsula generated 37 bids Wednesday, with a major oil company winning the most. Shell Offshore Inc., part of Shell Exploration & Production Co., was the high bidder on 33 tracts, all centered near Port Moeller. The site is southeast of Nelson Lagoon, about 580 miles southwest of Anchorage. Hewitt Mineral Corp. of Ardmore, Okla., was high bidder on four tracts in the same area. Alaska offered 1,047 tracts covering about 5.8 million acres, an area about the size of New Hampshire. The sale acreage available stretched from the Nushagak Peninsula in the north, down the north side of the Alaska Peninsula, to an area north of Cold Bay, including offshore tracts. The bids generated about $1.3 million. The minimum bid was $5 per acre. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img read more

Defender Taiwo being linked with move to Portugal

first_imgBenfica are being linked with a move for Taye Taiwo.The Nigerian left-back, who spent the second half of last season on loan at QPR from AC Milan, expects to leave the San Siro on a permanent basis this summer.“If Benfica are considering signing me for the next season, then I can only thank them for showing an interest in me,” Taiwo was quoted as saying by O Jogo.“My plan is to develop and improve myself every year and next season it will also be like that. Benfica would be a good club for me to develop and improve myself.”This page is regularly updated.Follow West London Sport on Twitter Find us on Facebooklast_img read more

WorkHands Wants To Become The Blue-Collar LinkedIn

first_imgA Comprehensive Guide to a Content Audit lauren orsini According to the most recent statistics from the Kaiser Family Foundation, blue collar workers make up roughly 60% of the workforce in each U.S. state.  However, you’d never know that browsing the Internet.While there are dozens of job boards that specialize in white collar jobs, if you’re looking for a skilled labor job, your best bet is to check your local Craigslist listings. The staff of WorkHands, is hoping to change that. A LinkedIn-like service for blue collar workers in the U.S., a new social network that launched Tuesday. Putting The Internet To WorkA software engineer, WorkHands CEO Patrick Cushing is the black sheep of his blue collar family. His dad fixed oil burners for a living, and his brother is a professional welder. He realized first hand that blue collar workers are always online, even if their jobs are not. “My brother has had Facebook since the beginning,” he said. “I looked at someone like my brother and realized he had all these online tools for his social life and none for his work career.”Perhaps because of the white collar backgrounds of most Silicon Valley types, most job networks are designed with similar job hunters in mind. There are thousands of blue collar professionals connected on LinkedIn, but Cushing argues that network doesn’t cater to them as specifically as WorkHands does. “Linkedin makes it really hard to demonstrate what you’re great at in the trades,” he said. “If you’re a great welder, one of the best ways to demonstrate that is to show your welds.”A machinist’s profile on WorkHands.In the same vein, the most prominent part of any WorkHands profile is a photo gallery. In this early adopter’s profile, photos of the student’s metalwork are placed more prominently than his experience or education history. Just like skillful code can be a ready calling card for a tech job, a well-welded piece of metal may be all a trades employer needs to see. WorkHands profiles also include sections you’d never see on LinkedIn, such as a place for workers to list the types of power tools they own and can use or a list of the workers’ licenses and certifications, used for operating heavy machinery or driving utility vehicles. But through testers, the WorkHands crew has met with the most enthusiasm with the photo gallery feature. “So many of the workers we talk to, we ask about their work and they pull out their phone and have pages and pages of photos of it,” said Cushing.  “They’re inherently proud of the work they do with their hands.”Keeping Social GoingFor this reason, the WorkHands crew believes that it can keep workers using the network even after they’ve already found a job. They can upload photos and approve of connections’ handiwork by clicking the “solid” button, a straight-talking version of Facebook’s “like.” Other features are on the way, too. This quarter, Cushing hopes to launch private networks for technical schools, employers, and other organizations, a mobile app, and a job board. Right now WorkHands is free for workers and employers alike, but eventually the network will make money by charging companies for their job listings. Already, WorkHands has helped a handful of students at Laney College in Oakland, CA find jobs at a local ironworking company. The network has worked well for students, who are already constantly online, and for companies, which before have never had a network to find welders, woodworkers, and other skilled laborers all in one place. The blue collar Internet already existed, said Cushing. They just needed the right tools.“The assumption that this workforce isn’t already online is something we’re really trying to challenge,” said Cushing.Image of WorkHands team courtesy of WorkHands. Tags:#Blue Collar#employment#LinkedIn Facebook is Becoming Less Personal and More Pro…center_img Related Posts The Dos and Don’ts of Brand Awareness Videos Guide to Performing Bulk Email Verificationlast_img read more

Common Consumer Frauds & How to Avoid Them Webinar

first_imgThe next Personal Finance webinar will be held Thursday, March 20 at 11 a.m. ET. Dr. Barbara O’Neill will present Common Consumer Frauds & How to Avoid Them.Several groups of Americans are particularly susceptible to fraudulent practices including older adults and young enlisted service members. In addition, some frauds, such as hacked data bases, are beyond an  individuals’ ability to control. Thus, everyone needs to know about common consumer frauds and how to reduce the risk of becoming a fraud victim. This 90-minute webinar will focus on three common types of consumer frauds: identity theft, investment fraud, and income tax refund fraud. It includes a description of fraud risk factors, a personalized identity theft risk assessment quiz, resources for personal and/or professional use, research findings about identity theft risk reduction practices, and a discussion of how to adjust income tax withholding to have a low or no refund for potential tax identity thieves to steal.)To join this webinar, simply go to the event page a few minutes before 11 a.m. ET on March 20 and click on the location link. Enter the room as  a guest. If you have not joined one of our webinars in the past or if you will not be joining from a military installation, you may need to install security certificates. Instructions are available here. The slides and other resources for this webinar will be available here. We hope to see you online on March 20!This post was published on the Military Families Learning Network blog on March 18, 2014.last_img read more

How did the ‘Berlin patient’ rid himself of HIV?

first_imgHIV resurfaces in ‘Mississippi baby’ many presumed cured Researchers are closer to unraveling the mystery of how Timothy Ray Brown, the only human cured of HIV, defeated the virus, according to a new study. Although the work doesn’t provide a definitive answer, it rules out one possible explanation.Brown remains one of the most studied cases in the HIV epidemic’s history. In 2006, after living with the virus for 11 years and controlling his infection with antiretroviral drugs (ARVs), he learned that he had developed acute myeloid leukemia. (The leukemia has no known relationship to HIV infection or treatment.) Chemotherapy failed, and the next year Brown, an American then living in Berlin, received the first of two bone marrow transplants—a common treatment for this cancer—and ditched his ARVs. When HIV-infected people stop taking ARVs, levels of HIV typically skyrocket within weeks. Yet researchers scouring Brown’s blood over the past 7 years have found only traces of the viral genetic material, none of which can replicate.Today, researchers point to three different factors that could independently or in combination have rid Brown’s body of HIV. The first is the process of conditioning, in which doctors destroyed Brown’s own immune system with chemotherapy and whole body irradiation to prepare him for his bone marrow transplant. His oncologist, Gero Hütter, who was then with the Free University of Berlin, also took an extra step that he thought might not only cure the leukemia but also help rid Brown’s body of HIV. He found a bone marrow donor who had a rare mutation in a gene that cripples a key receptor on white blood cells the virus uses to establish an infection. (For years, researchers referred to Brown as “the Berlin patient.”) The third possibility is his new immune system attacked remnants of his old one that held HIV-infected cells, a process known as graft versus host disease.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)In the new study, a team led by immunologist Guido Silvestri of Emory University in Atlanta, designed an unusual monkey experiment to test these possibilities.Bone marrow transplants work because of stem cells. Modern techniques avoid actually aspirating bone marrow, and instead can sift through blood and pluck out the stem cells needed for a transplant to “engraft.” So the researchers first drew blood from three rhesus macaque monkeys, removed stem cells, and put the cells in storage. They then infected these animals and three control monkeys with a hybrid virus, known as SHIV, that contains parts of the simian and human AIDS viruses. All six animals soon began receiving ARVs (which respond better to SHIVs than SIV itself), and SHIV levels in the blood quickly dropped below the level of detection on standard tests, as expected.A few months later, the three monkeys that had stored stem cells underwent whole body irradiation to condition their bodies and then had their own stem cells reinfused. After the cells engrafted, a process that took a few more months, the researchers stopped ARVs in the three animals and in the three controls. SHIV quickly came screaming back in the three controls and two of the transplanted animals. (One of the transplanted monkeys did not have the virus rebound but its kidneys failed and the researchers euthanized it.)The team, which publishes its work online in PLOS Pathogens today, concludes that conditioning by itself likely cannot rid the body of the AIDS virus. Silvestri explains that the monkey study was a proof-of-principle experiment that cleanly isolated the effects of conditioning alone. “There’s no way to do this in humans,” he says. “It’s an important study and it’s a very useful model,” says Daniel Kuritzkes of Brigham & Women’s Hospital in Cambridge, Massachusetts, who wasn’t connected to the research.Kuritzkes and colleagues are particularly interested in the experiment because two of their own HIV-infected patients with leukemia received bone marrow transplants from donors who did not have HIV-resistant cells. For several months after stopping ARVs, HIV remained at bay in both men, raising hopes that the resistant donor cells were not a factor. But the virus eventually returned in each patient. Kuritzkes suspects that the transplants did reduce the amount of HIV left in the patients’ bodies—known as the viral reservoir—but the virus resurfaced because it continued to copy itself and eventually overwhelmed the immune responses against it.Although the study shows that conditioning by itself likely cannot eliminate an HIV infection, the study leaves open the possibility that graft versus host disease played a central role in Brown’s cure. Unlike Brown and Kuritzkes’s two patients, the transplanted monkeys received their own stem cells, which did not trigger a graft versus host response. “At the end of the day that might be an important component,” Silvestri says. He also thinks it might help reduce the reservoir size to treat monkeys with ARVs for longer than a few months.Silvestri hopes to do future monkey experiments that test the different variables, including transplanting the animals with viral-resistant blood cells that mimic the ones that Brown received. “The best scientific studies raise as many questions as answers,” says Steven Deeks, a researcher and clinician at the University of California, San Francisco, who has treated and studied Brown. “Unfortunately, the heroic efforts that went into this study failed to provide a definitive answer regarding the riddles of the Berlin patient. The model will likely need to be further optimized, and at the very least, the macaques treated with antiretroviral therapy for longer periods of time. But I am confident the team will figure this out.”Related content:Strategies against HIV/AIDS Cure setbacks force HIV researchers to reset sightslast_img read more